A look at 2025's Biggest Upsets.
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(Oct 4)    The UCLA Bruins beat the Penn State Nittany Lions as a 24.5 point home underdog.
(Oct 18)    The UAB Blazers beat the Memphis Tigers as a 23.5 point home underdog.
(Sep 6)    The Long Island University Sharks beat the Eastern Michigan Eagles as a 22.5 point road underdog.
(Nov 8)    The Sam Houston Bearkats beat the Oregon State Beavers as a 21 point road underdog.
(Oct 11)    The Northwestern Wildcats beat the Penn State Nittany Lions as a 20.5 point road underdog.
(Sep 6)    The South Florida Bulls beat the Florida Gators as a 18.5 point road underdog.
(Nov 8)    The California Golden Bears beat the Louisville Cardinals as a 18.5 point road underdog.
(Nov 1)    The Fresno State Bulldogs beat the Boise State Broncos as a 17.5 point road underdog.
(Sep 20)    The Syracuse Orange beat the Clemson Tigers as a 17.5 point road underdog.
(Oct 18)    The Stanford Cardinal beat the Florida State Seminoles as a 17.5 point home underdog.
(Sep 6)    The Army Black Knights beat the Kansas State Wildcats as a 17 point road underdog.
(Sep 12)    The New Mexico Lobos beat the UCLA Bruins as a 15.5 point road underdog.
(Sep 6)    The Bryant Bulldogs beat the Massachusetts Minutemen as a 14.5 point road underdog.
(Aug 30)    The Austin Peay Governors beat the Middle Tennessee Blue Raiders as a 14.5 point road underdog.
(Aug 30)    The Rice Owls beat the Louisiana Ragin' Cajuns as a 14.5 point road underdog.
(Sep 20)    The Coastal Carolina Chanticleers beat the South Alabama Jaguars as a 14.5 point road underdog.
(Oct 11)    The Marshall Thundering Herd beat the Old Dominion Monarchs as a 14.5 point home underdog.
(Aug 29)    The Tarleton State Texans beat the Army Black Knights as a 14.5 point road underdog.
(Oct 4)    The Ball State Cardinals beat the Ohio Bobcats as a 14.0 point home underdog.
(Oct 4)    The Arkansas State Red Wolves beat the Texas State Bobcats as a 14.0 point home underdog.
(Sep 13)    The Stanford Cardinal beat the Boston College Eagles as a 14.0 point home underdog.
(Sep 20)    The San Diego State Aztecs beat the California Golden Bears as a 14.0 point home underdog.
(Sep 20)    The Western Michigan Broncos beat the Toledo Rockets as a 13.5 point home underdog.
(Nov 1)    The West Virginia Mountaineers beat the Houston Cougars as a 13.5 point road underdog.
(Aug 30)    The Florida State Seminoles beat the Alabama Crimson Tide as a 13.5 point home underdog.
(Dec 27)    The East Carolina Pirates beat the Pittsburgh Panthers as a 13.5 point home underdog.
(Nov 29)    The California Golden Bears beat the SMU Mustangs as a 13.5 point home underdog.
(Aug 29)    The Central Michigan Chippewas beat the San José State Spartans as a 11.5 point road underdog.
(Nov 15)    The Sam Houston Bearkats beat the Delaware Blue Hens as a 11.5 point home underdog.
(Nov 1)    The Kentucky Wildcats beat the Auburn Tigers as a 11.5 point road underdog.
(Sep 20)    The Maryland Terrapins beat the Wisconsin Badgers as a 10.5 point road underdog.
(Oct 11)    The Bowling Green Falcons beat the Toledo Rockets as a 10.5 point home underdog.
(Nov 8)    The Wisconsin Badgers beat the Washington Huskies as a 10.5 point home underdog.
(Oct 18)    The Coastal Carolina Chanticleers beat the App State Mountaineers as a 10.5 point road underdog.
(Nov 29)    The Georgia Southern Eagles beat the Marshall Thundering Herd as a 10.5 point road underdog.
(Oct 11)    The Pittsburgh Panthers beat the Florida State Seminoles as a 10.5 point road underdog.
(Oct 17)    The Louisville Cardinals beat the Miami Hurricanes as a 10.5 point road underdog.
(Sep 19)    The Tulsa Golden Hurricane beat the Oklahoma State Cowboys as a 10.5 point road underdog.
(Oct 25)    The Rice Owls beat the UConn Huskies as a 10.5 point home underdog.
(Oct 25)    The Akron Zips beat the Buffalo Bulls as a 10 point road underdog.
(Nov 15)    The Nevada Wolf Pack beat the San José State Spartans as a 10.0 point home underdog.
(Sep 27)    The Virginia Tech Hokies beat the NC State Wolfpack as a 10 point road underdog.
(Nov 22)    The Tulsa Golden Hurricane beat the Army Black Knights as a 10 point road underdog.